Diagnostic performance for pulmonary adenocarcinoma on CT: comparison of radiologists with and without three-dimensional convolutional neural network

概要

Objectives To compare diagnostic performance for pulmonary invasive adenocarcinoma among radiologists with and without three-dimensional convolutional neural network (3D-CNN). Methods Enrolled were 285 patients with adenocarcinoma in situ (AIS, n = 75), minimally invasive adenocarcinoma (MIA, n = 58), and invasive adenocarcinoma (IVA, n = 152). A 3D-CNN model was constructed with seven convolution-pooling and two max-pooling layers and fully connected layers, in which batch normalization, residual connection, and global average pooling were used. Only the flipping process was performed for augmentation. The output layer comprised two nodes for two conditions (AIS/MIA and IVA) according to prognosis. Diagnostic performance of the 3D-CNN model in 285 patients was calculated using nested 10-fold cross-validation. In 90 of 285 patients, results from each radiologist (R1, R2, and R3; with 9, 14, and 26 years of experience, respectively) with and without the 3D-CNN model were statistically compared. Results Without the 3D-CNN model, accuracy, sensitivity, and specificity of the radiologists were as follows: R1, 70.0%, 52.1%, and 90.5%; R2, 72.2%, 75%, and 69%; and R3, 74.4%, 89.6%, and 57.1%, respectively. With the 3D-CNN model, accuracy, sensitivity, and specificity of the radiologists were as follows: R1, 72.2%, 77.1%, and 66.7%; R2, 74.4%, 85.4%, and 61.9%; and R3, 74.4%, 93.8%, and 52.4%, respectively. Diagnostic performance of each radiologist with and without the 3D-CNN model had no significant difference (p > 0.88), but the accuracy of R1 and R2 was significantly higher with than without the 3D-CNN model (p < 0.01). Conclusions The 3D-CNN model can support a less-experienced radiologist to improve diagnostic accuracy for pulmonary invasive adenocarcinoma without deteriorating any diagnostic performances. Key Points • The 3D-CNN model is a non-invasive method for predicting pulmonary invasive adenocarcinoma in CT images with high sensitivity. • Diagnostic accuracy by a less-experienced radiologist was better with the 3D-CNN model than without the model.

収録
European Radiology
新岡宏彦
新岡宏彦
招へい准教授

深層学習による様々なバイオイメージングデータの分類、医療データを用いた診断補助に従事。光学顕微鏡(蛍光顕微鏡、第二近赤外顕微鏡、ラマン顕微鏡など)によるデータベース作成と分類。CT画像やヘルスケアデータを扱う。

長原一
長原一
教授

コンピューテーショナルフォトグラフィ、コンピュータビジョンを専門とし実世界センシングや情報処理技術、画像認識技術の研究を行う。さらに、画像センシングにとどまらず様々なセンサに拡張したコンピュテーショナルセンシング手法の開発や高次元で冗長な実世界ビッグデータから意味のある情報を計測するスパースセンシングへの転換を目指す。

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